Metabolic Signatures of Acinetobacter baumannii and Klebsiella pneumoniae Infections in Acute-on-chronic Liver Failure
Our findings suggest that metabolites associated with bacterial infections and hepatotoxic potential are significantly elevated in patients with AD and ACLF. These compounds may contribute to disease-related metabolic disturbances, representing promising candidates as early diagnostic biomarkers and targeted therapeutic strategies for ACLF.
Authors
- Sania Arif (ORCID: https://orcid.org/0000-0001-5223-2047)
- Lisa Hahnefeld (ORCID: https://orcid.org/0000-0002-0382-5695)
- Christoph Welsch (ORCID: https://orcid.org/0000-0002-1823-4863)
- Volkhard A. J. Kempf (ORCID: https://orcid.org/0000-0002-3321-7551)
- Wibke Ballhorn
- Florence Castelli (ORCID: https://orcid.org/0000-0002-6886-8549)
- Maximilian Joseph Brol (ORCID: https://orcid.org/0000-0003-2879-7560)
- Jonel Trebicka (ORCID: https://orcid.org/0000-0002-7028-3881)
- Robert Schierwagen (ORCID: https://orcid.org/0000-0002-2195-3666)
- Hans‐Peter Erasmus
- Frank Erhard Uschner (ORCID: https://orcid.org/0000-0002-3760-2887)
- Angela Brieger (ORCID: https://orcid.org/0000-0003-1089-9710)
- Volker Müller (ORCID: https://orcid.org/0000-0001-7955-5508)
- Julia Fischer (ORCID: https://orcid.org/0000-0001-6138-7454)
- Nico Kraus (ORCID: https://orcid.org/0000-0002-5162-1048)
- Robert Gurke (ORCID: https://orcid.org/0000-0001-8218-1295)
- Christophe Junot (ORCID: https://orcid.org/0000-0003-0019-6827)
- Sara Garcia Torres
- Cristina Ortíz (ORCID: https://orcid.org/0000-0002-9049-5785)
- Camilla Cadoli
Institutions
- Goethe University Frankfurt (DE)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris-Saclay (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- European Foundation for the Study of Chronic Liver Failure (ES)
- University Hospital Münster (DE)
- Fraunhofer Institute for Translational Medicine and Pharmacology (DE)
- CEA Paris-Saclay (FR)
- University Hospital Frankfurt (DE)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101707
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 0.00