Trigeminal nerve stimulation modulates dopaminergic circuits and neuroinflammation to alleviate depression
TNS alleviates depressive-like behaviors through TG TRPV1<sup>+</sup> neurons and PVN-VTA-NAc circuit activation, with D1/D2 receptors mediating acute effects and D3 receptors maintaining lasting anti-inflammatory benefits.
Authors
- Chao Ma (ORCID: https://orcid.org/0000-0002-7724-0630)
- Lifang Huo
- Shengnuo Fan (ORCID: https://orcid.org/0000-0003-1372-8474)
- Qian Yang (ORCID: https://orcid.org/0000-0003-1998-1593)
- Lijiaqi Liu (ORCID: https://orcid.org/0000-0001-8071-8634)
- Qian Zhang (ORCID: https://orcid.org/0000-0002-1774-9726)
- Haiyun Ma
- Shaoling Wu (ORCID: https://orcid.org/0000-0002-7477-2711)
- Congping Shang (ORCID: https://orcid.org/0000-0002-1042-4021)
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Brain stimulation
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1016/j.brs.2025.103005
- Primary Topic
- Vagus Nerve Stimulation Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00