Acellular placental extract outcomes in post-traumatic osteoarthritis model
HPE may be a promising treatment for OA by inhibiting the metabolic process of ECM breakdown and preserving the structural integrity of the knee joint in comparison to saline control.
Authors
- John S. Shields
- Marcel G. Brown (ORCID: https://orcid.org/0000-0003-1553-5684)
- Ayobami S. Ogunsola (ORCID: https://orcid.org/0000-0002-5774-1163)
- Seth Tomblyn (ORCID: https://orcid.org/0009-0006-2445-2484)
- Kaitlin Henry (ORCID: https://orcid.org/0009-0004-6012-8097)
- Xue Ma (ORCID: https://orcid.org/0000-0003-2329-5350)
- Matthew S. Gwilt (ORCID: https://orcid.org/0009-0000-4685-486X)
- Thomas L. Smith (ORCID: https://orcid.org/0000-0003-0975-5090)
- Scott A. Washburn (ORCID: https://orcid.org/0000-0002-3645-2645)
- Jesse Champi (ORCID: https://orcid.org/0009-0005-8474-0827)
Institutions
- Io Therapeutics (United States) (US)
- Wake Forest University (US)
Publication Details
- Journal
- Osteoarthritis and Cartilage Open
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1016/j.ocarto.2025.100729
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00