Comprehensive multi‐omics mapping of immune perturbations in autism spectrum disorder
T cell dysregulation, NK cell impairment, and myeloid expansion indicate a chronic inflammatory state and immune exhaustion phenotype associated with ASD severity. Plasma metabolomic and proteomic alterations, including disrupted oxidative phosphorylation and elevated inflammatory markers, correlate with ASD severity and highlight potential biomarkers. Multi-omics profiling links peripheral immune dysregulation to neurodevelopmental abnormalities, providing a framework for immune-targeted ASD interventions.
Authors
- Chaoting Lan (ORCID: https://orcid.org/0000-0002-6363-9587)
- Chun Yan
- Wen‐Xiong Chen (ORCID: https://orcid.org/0000-0001-9076-2006)
- Yinchun Chen
- Xiaoli Huang (ORCID: https://orcid.org/0000-0002-2833-3523)
- Yufeng Liu (ORCID: https://orcid.org/0009-0002-4794-3316)
- Liangqiong Deng
- Gang Luo (ORCID: https://orcid.org/0000-0003-1544-1434)
- Huijuan Wang (ORCID: https://orcid.org/0000-0002-6044-7416)
- Yuling Yang
- Fangmei Feng
- Yuxin Wu (ORCID: https://orcid.org/0000-0001-5625-1413)
- Xiaotao Jiang (ORCID: https://orcid.org/0000-0002-4519-4289)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Liuzhou Maternal and Child Health Hospital (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- First Affiliated Hospital of Guangzhou University of Chinese Medicine (CN)
- Guangzhou Women and Children Medical Center (CN)
- Guangzhou First People's Hospital (CN)
- Community Health Center (US)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/ctm2.70552
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00