Oncofetal dual‑specificity phosphatase 9 drives stem‐like properties through ERK1/2‐PPARG‐SCD axis‐mediated lipid metabolism in hepatocellular carcinoma
Oncofetal reprogramming-based prognostic signature robustly stratifies HCC patient survival across independent cohorts. DUSP9 is identified as a core oncofetal regulator that drives stem-like traits in HCC. Mechanistically, DUSP9 suppresses ERK1/2-phosphorylation, stabilizes PPARG, and transcriptionally activates SCD. The DUSP9-ERK1/2-PPARG-SCD axis remodels lipid metabolism to support proliferation, cell mobility, and sorafenib resistance.
Authors
- Hai Hui Huang (ORCID: https://orcid.org/0000-0001-7430-0119)
- Mengdie Cao (ORCID: https://orcid.org/0000-0001-6773-3952)
- Shuya Bai (ORCID: https://orcid.org/0009-0003-9333-0817)
- Shiru Chen
- Yuchong Zhao (ORCID: https://orcid.org/0000-0003-2245-8541)
- Bin Cheng (ORCID: https://orcid.org/0000-0003-1568-8760)
- Peng Wang (ORCID: https://orcid.org/0000-0002-2631-971X)
- Luyao Liu (ORCID: https://orcid.org/0000-0001-5241-967X)
- Wei Chen (ORCID: https://orcid.org/0000-0002-9394-9834)
- Qiaodan Zhou
- Jingwen Liang (ORCID: https://orcid.org/0009-0000-7973-2818)
- Si Xiong
Institutions
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/ctm2.70550
- Citations
- 1
- Primary Topic
- Protein Tyrosine Phosphatases
- Type
- article
- Field-Weighted Citation Impact
- 0.81