Cytogenetic Effects of Conventional and Ultra High Dose Rates of Radiation in Human Lymphocytes: Comparative Analysis in Metaphase Chromosomes and G2-PCCs
The reduced yields of chromosomal aberrations detected after UHDR of electrons may be due to rapid delivery of radiation dose within seconds, resulting in a non-uniform exposure of lymphocytes with varying levels of DNA damage induction. Future studies using well defined human equivalent in vivo and in vitro model systems are required to determine the underlying mechanisms for the FLASH effects.
Authors
- Adayabalam S. Balajee (ORCID: https://orcid.org/0000-0001-9957-1513)
- Terri L. Ryan
- Maria B. Escalona (ORCID: https://orcid.org/0000-0002-3140-2526)
- Carol J. Iddins (ORCID: https://orcid.org/0000-0002-7777-3760)
- Samantha R. Gross
- Helen C. Turner (ORCID: https://orcid.org/0000-0002-3087-4740)
Institutions
- Oak Ridge Associated Universities (US)
- Columbia University Irving Medical Center (US)
- Oak Ridge Institute for Science and Education
- University of Tennessee at Knoxville (US)
Publication Details
- Journal
- Disaster Medicine and Public Health Preparedness
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1017/dmp.2025.10093
- Primary Topic
- Carcinogens and Genotoxicity Assessment
- Type
- article
- Field-Weighted Citation Impact
- 0.00