Single-cell and bulk transcriptomics reveal a CD8+ T-cell gene signature predicting prognosis in diffuse large B-cell lymphoma
This study highlights CD8+ T cell heterogeneity in DLBCL and establishes a prognostic gene signature that informs patient survival prediction and CAR-T therapy efficacy.
Authors
- Wenchen Gong (ORCID: https://orcid.org/0000-0002-7637-3538)
- Yingfang Feng (ORCID: https://orcid.org/0000-0002-5034-8879)
- Lihua Qiu (ORCID: https://orcid.org/0000-0003-4637-1811)
- Jin He (ORCID: https://orcid.org/0000-0001-6580-8957)
- Hengqi Liu
- L. Li (ORCID: https://orcid.org/0009-0009-4088-4430)
- Muhammad Asghar (ORCID: https://orcid.org/0000-0002-5377-8188)
- Hassan Abolhassani (ORCID: https://orcid.org/0000-0002-4838-0407)
- Bin Meng (ORCID: https://orcid.org/0000-0003-4214-7011)
- Xianhuo Wang (ORCID: https://orcid.org/0000-0001-8742-4348)
- Huilai Zhang (ORCID: https://orcid.org/0000-0002-0091-0026)
- Xia Liu (ORCID: https://orcid.org/0000-0002-0180-2166)
- Ning Zhang (ORCID: https://orcid.org/0000-0002-3974-6921)
- Shiyong Zhou
- Zhengzi Qian
- Zheng Song
- Jingwei Yu (ORCID: https://orcid.org/0009-0002-1045-1318)
Institutions
- Jiangsu University (CN)
- Xuzhou Medical College (CN)
- University of Southern Denmark (DK)
- Lund University (SE)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Karolinska Institutet (SE)
- Xuzhou Cancer Hospital (CN)
- Children's Medical Center (IR)
- National University of Sciences and Technology (PK)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-12
- DOI
- https://doi.org/10.3389/fimmu.2025.1685541
- Citations
- 1
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 1.05