First establishment of population-specific brain volume reference standards for Chinese children and adolescents: an AI-based segmentation study

This study is the first to establish reference values for brain volume in healthy Chinese children and adolescents aged 6-18 years using AI-based automated segmentation. It reveals sex- and age-related differences in brain structural development, thereby providing a valuable quantitative reference for future research on brain development deviations. These population-specific standards may provide a theoretical foundation for improving diagnostic accuracy in Chinese children, though their actual utility in reducing misclassification requires future empirical validation.