Lactobacillus amplifies DHAMaR1 conversion to attenuate intestinal ischemia-reperfusion injury via decreasing pyroptosis
MaR1 and its precursor DHA confer robust protection against intestinal I/R injury by suppressing RORα-driven pyroptosis. The probiotic-mediated amplification of MaR1 biosynthesis highlights a novel microbiota-lipid mediator crosstalk with translational potential. These findings support combinatorial interventions leveraging host-microbe interactions as a promising therapeutic avenue for ischemic intestinal injury.
Authors
- Chenghao Qiu (ORCID: https://orcid.org/0009-0003-4847-0183)
- Hongxing Cai (ORCID: https://orcid.org/0000-0001-5677-7909)
- Wenjing Xian
- Jianbo Zhang (ORCID: https://orcid.org/0000-0003-2705-8547)
- Tong Li (ORCID: https://orcid.org/0000-0002-4283-0091)
- Peng Zhu (ORCID: https://orcid.org/0000-0003-4795-2730)
- Shiji Zhou
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-12
- DOI
- https://doi.org/10.3389/fimmu.2025.1712761
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00