Coreopsis tinctoria Nutt. attenuates ultraviolet A photodamage by suppressing endoplasmic reticulum stress-induced apoptosis via Nrf2 crosstalk
CT alleviates UVA-induced skin photodamage by concurrently inhibiting all three branches of ER stress and activating Nrf2-driven antioxidant defenses, thereby modulating apoptosis. These findings position CT as a promising natural agent for dermocosmetic and therapeutic strategies against UVA-mediated skin injury.
Authors
- Xiwei Wu (ORCID: https://orcid.org/0000-0002-7071-1671)
- Ling Liang (ORCID: https://orcid.org/0000-0002-3115-2563)
- Nan Zhao (ORCID: https://orcid.org/0000-0002-5218-1048)
- Cheuk‐Lun Lee (ORCID: https://orcid.org/0000-0003-1553-3478)
- Jiangming Zhong (ORCID: https://orcid.org/0000-0002-4131-5522)
- Zhiwei Li (ORCID: https://orcid.org/0000-0001-8031-6547)
- Mingjie Li (ORCID: https://orcid.org/0000-0003-3470-1844)
- Peng Shu (ORCID: https://orcid.org/0000-0002-3888-0192)
- Man Wu (ORCID: https://orcid.org/0009-0005-5638-0131)
- Xin Nie
- Menggeng Li
Institutions
- Hong Kong Polytechnic University (HK)
- Dà-Jiāng Innovations Science and Technology (China) (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-12-12
- DOI
- https://doi.org/10.3389/fphar.2025.1686234
- Primary Topic
- Skin Protection and Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00