A trans-activating transduction peptide fused nanobody targeting viral nonstructural protein NS4B inhibits bovine viral diarrhea virus replication
These findings demonstrate that a cell-penetrating nanobody targeting the conserved viral protein NS4B can effectively inhibit BVDV replication across relevant cell types and biotypes. This establishes TAT-fused nanobodies as a promising new therapeutic strategy against BVDV.
Authors
- Junyang Fang (ORCID: https://orcid.org/0009-0006-3421-1107)
- Zehao Lv (ORCID: https://orcid.org/0000-0001-7108-5310)
- Wenqi Fan (ORCID: https://orcid.org/0000-0002-4726-1959)
- Xuefeng Qi (ORCID: https://orcid.org/0000-0003-1786-1694)
- Ying Zhang (ORCID: https://orcid.org/0000-0001-6355-9205)
- Xiwen Chen (ORCID: https://orcid.org/0000-0003-0170-4459)
- Shuang Wei (ORCID: https://orcid.org/0000-0002-9404-9205)
- Ni Huang
- Bao Zhao
- Lizhen Wang
Institutions
- Mianyang Normal University (CN)
- North West Agriculture and Forestry University (CN)
- Mianyang City Center for Disease Control and Prevention (CN)
- ES Technology (United Kingdom) (GB)
- Ministry of Agriculture and Rural Affairs (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-12
- DOI
- https://doi.org/10.3389/fimmu.2025.1712683
- Primary Topic
- Animal Disease Management and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00