Brucella melitensis clinical isolate modulates osteoclast differentiation to drive pathological bone destruction in brucellar arthritis
These findings elucidate the mechanisms underlying pathological bone defects in brucellar arthritis. The direct bacterial effects, together with the formation of an osteoclast-derived pro-survival niche, account for the prevalence of brucellar arthritis as the most common complication of chronic brucellosis. Targeting the interaction between <i>B. melitensis</i> and osteoclasts may thus offer a novel therapeutic strategy for preventing and treating <i>Brucella</i>-induced osteolytic lesions.
Authors
- Mengru Su
- Jinlei Chen (ORCID: https://orcid.org/0000-0003-3775-3586)
- Jiying Tuo (ORCID: https://orcid.org/0000-0003-0694-5374)
- Yuefeng Chu (ORCID: https://orcid.org/0000-0002-9443-2677)
- Guanghai Zhao
- Feijie Zhi (ORCID: https://orcid.org/0000-0001-7572-1281)
- Wei Song (ORCID: https://orcid.org/0000-0002-3182-8906)
- Haihong Zhang (ORCID: https://orcid.org/0000-0003-3765-1942)
Institutions
- Lanzhou Veterinary Research Institute (CN)
- Ministry of Agriculture (EE)
- Lanzhou University Second Hospital (CN)
- Ministry of Agriculture (CA)
- Ministry of Agriculture and Rural Affairs (CN)
- Gansu Provincial Center for Disease Control and Prevention (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-12-12
- DOI
- https://doi.org/10.3389/fcimb.2025.1694633
- Primary Topic
- Brucella: diagnosis, epidemiology, treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Lanzhou University
- National Natural Science Foundation of China
- Chinese Academy of Agricultural Sciences
- Agricultural Science and Technology Innovation Program