Sex differences in heart failure mortality by ejection fraction subtype: a single-center, retrospective cohort study
Age is a significant independent risk factor for all-cause mortality in HF patients, with female sex emerging as a critical predictor in the HFmrEF subtype. These findings highlight the need for sex-specific risk stratification and tailored management strategies, particularly for females with HFmrEF. Future prospective, multi-center studies are needed to validate these results and explore underlying mechanisms to optimize HF outcomes.
Authors
- Fengwei Liang (ORCID: https://orcid.org/0009-0006-7636-6844)
- Xiaohan Hu (ORCID: https://orcid.org/0000-0002-5608-2864)
- Dandan Tang (ORCID: https://orcid.org/0000-0001-9963-1301)
- Abiden Kapar (ORCID: https://orcid.org/0009-0007-6891-4756)
- Xingli Gu
Institutions
- Xinjiang Medical University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
- Sanya University (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-12-12
- DOI
- https://doi.org/10.3389/fcvm.2025.1686845
- Primary Topic
- Heart Failure Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Xinjiang Medical University
- Natural Science Foundation of Xinjiang