Integrated analysis of the relationship between metabolic pathways and immune infiltration in rheumatoid arthritis
Metabolic pathways, particularly the TCA cycle, play a critical role in the pathogenesis of RA. Eleven key hub genes were identified as being involved in metabolic reprogramming associated with immune infiltration, and the LASSO model incorporating these genes demonstrated strong diagnostic potential for RA. Notably, COX7C might contribute to RA progression by dysregulating cellular metabolic processes.
Authors
- Yuming Huang (ORCID: https://orcid.org/0000-0001-7775-6787)
- Lin Qi (ORCID: https://orcid.org/0000-0003-2491-2701)
- Zhiming Zhang (ORCID: https://orcid.org/0000-0001-5112-8387)
- Chaofeng Zhang (ORCID: https://orcid.org/0000-0002-1504-305X)
- Zhongyi You
- Zhiqun Pan
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
- Putian University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-12
- DOI
- https://doi.org/10.3389/fimmu.2025.1679356
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province
- Putian University