Exploring HSP90α and hs-CRP using AI models to predict prognosis in advanced hepatocellular carcinoma treated with PD-1 inhibitors and targeted therapy
HSP90α and hs-CRP, plays a critical role in the prognosis of advanced HCC. Integrating these biomarkers with machine learning models enhances OS prediction accuracy, offering a personalized approach to cancer treatment.
Authors
- Zhen-Ying Wu (ORCID: https://orcid.org/0000-0002-4789-4545)
- Yue Tu (ORCID: https://orcid.org/0000-0001-5592-4751)
- Wenting Du (ORCID: https://orcid.org/0000-0001-6765-0129)
- Pan Wang (ORCID: https://orcid.org/0000-0002-6863-2050)
- Qian Wei (ORCID: https://orcid.org/0009-0005-4512-4714)
- Lianbin Wen
- Xian‐Guo Liu (ORCID: https://orcid.org/0000-0002-4352-8687)
- Hongyan Li (ORCID: https://orcid.org/0000-0002-7073-5198)
- Lu Yang (ORCID: https://orcid.org/0000-0001-9566-6259)
- Junqi Liu (ORCID: https://orcid.org/0000-0002-6015-1033)
- Xueting Li (ORCID: https://orcid.org/0000-0002-6868-5929)
- Yuxin Shi (ORCID: https://orcid.org/0000-0002-1065-2809)
- Yanqiong Song (ORCID: https://orcid.org/0000-0002-8955-2471)
Institutions
- University of Electronic Science and Technology of China (CN)
- Chongqing University (CN)
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- First Affiliated Hospital of Sichuan Medical University (CN)
- Panzhihua University (CN)
- Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (CN)
- Sichuan Cancer Hospital (CN)
- Panzhihua Central Hospital (CN)
- First People's Hospital of Chongqing (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-12-12
- DOI
- https://doi.org/10.3389/fphar.2025.1726967
- Primary Topic
- Heat shock proteins research
- Type
- article
- Field-Weighted Citation Impact
- 0.00