Effects of high-altitude environments on intervertebral disc degeneration and transcriptome profiling of the nucleus pulposus
Our findings clarify the effects of high altitude on disc degeneration and predict potential molecular targets that can be used to identify or intervene in disc degeneration caused by high altitude by mining the common features of NP cells associated with the aging process in HA environments through transcriptome sequencing.
Authors
- Rong Tang
- Jiawei Fu
- Tianfei Ran (ORCID: https://orcid.org/0000-0001-7751-9298)
- Bo Huang (ORCID: https://orcid.org/0000-0002-1849-7516)
- Yue Zhou (ORCID: https://orcid.org/0000-0002-4866-1655)
Institutions
- Army Medical University (CN)
- Xinqiao Hospital (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-12-12
- DOI
- https://doi.org/10.3389/fcell.2025.1709844
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00