P2RX1 promotes mitochondrial apoptosis via calcium/CaM KII-mediated suppression of PI3K/Akt signaling in Philadelphia chromosome-positive acute lymphoblastic leukemia
This study reveals the role of P2RX1 as a calcium-regulated tumor suppressor in Ph<sup>+</sup> ALL, promoting apoptosis by disrupting mitochondrial function and inhibiting the PI3K/Akt survival signaling pathway, thereby providing a novel therapeutic approach to overcome TKI resistance.
Authors
- Lei Feng (ORCID: https://orcid.org/0000-0002-4414-9910)
- X. Ye
- Jing Li (ORCID: https://orcid.org/0009-0008-1301-2533)
- Xiao Li (ORCID: https://orcid.org/0000-0002-2219-4630)
- Qin Ren
Institutions
- Harbin Medical University (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Frontiers in Pediatrics
- Published
- 2025-12-12
- DOI
- https://doi.org/10.3389/fped.2025.1730429
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00