Real-world disproportionality analysis of sleep disturbances associated with antiseizure medications in epilepsy: a pharmacovigilance study
This pharmacovigilance study reveals significant associations between various ASMs and sleep disturbances. The distinct disproportionality reporting profiles identified for some agents, which differ from prior evidence, necessitate careful clinical interpretation. Overall, this study elucidates the complex sleep safety profiles of ASMs, offering evidence to support more informed drug selection and monitoring in practice.
Authors
- Mengshi Yang
- Qingqing Zhao (ORCID: https://orcid.org/0000-0002-2932-9702)
- Yanbing Han (ORCID: https://orcid.org/0000-0002-6731-1335)
- Chen Gou
Institutions
- Kunming Medical University (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
- Yunnan Center for Disease Control And Prevention (CN)
- Yunnan Provincial Infectious Disease Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-12-12
- DOI
- https://doi.org/10.3389/fphar.2025.1740747
- Primary Topic
- Pharmacovigilance and Adverse Drug Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- NIH Clinical Center