Epidemiological, clinical characteristics and prognostic factors analysis of adult patients with hemophagocytic lymphohistiocytosis in a Chinese hospital
Despite advancements in pediatric HLH, adult HLH mortality remains high, driven by diagnostic delays, comorbid complexity, and lack of standardized protocols. Future efforts must prioritize: (1) adult-specific biomarkers for early diagnosis, (2) trigger-tailored immunotherapies, and (3) multidisciplinary care pathways to address multisystem involvement.
Authors
- Hua‐Guo Xu (ORCID: https://orcid.org/0000-0001-7170-9445)
- Yaman Wang (ORCID: https://orcid.org/0000-0002-9945-2802)
- Jun Zhou (ORCID: https://orcid.org/0000-0002-0716-3967)
- Min Wang (ORCID: https://orcid.org/0000-0001-5695-0257)
- Mingjun Xie (ORCID: https://orcid.org/0009-0008-6320-8868)
Institutions
- National Center for Clinical Laboratories (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-12
- DOI
- https://doi.org/10.3389/fimmu.2025.1684308
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Commission of Health
- Government of Jiangsu Province