Remarkable response to pembrolizumab in PD-L1 overexpressing (≥ 50%) NSCLC and extracranial abscopal effect induced by brain radiotherapy: a case report
This case highlights that an extracranial abscopal effect can occur following brain radiotherapy alone in lung adenocarcinoma patients with brain metastases and PD-L1 TPS ≥50%. For such patients, the combination of palliative brain radiotherapy and PD-1 antibody therapy may represent a safe and effective therapeutic strategy.
Authors
- Jinxing Lou
- Hui Xue (ORCID: https://orcid.org/0000-0002-9240-4357)
- Xinhong Guan
- Sheng‐Teng Huang (ORCID: https://orcid.org/0000-0002-7495-6115)
- Yong Xia (ORCID: https://orcid.org/0000-0003-0339-9929)
- Hongfan Zhu
- Xudong Chen (ORCID: https://orcid.org/0000-0002-7087-4075)
- Qian Zhang (ORCID: https://orcid.org/0000-0003-4928-3366)
- Meng Liu (ORCID: https://orcid.org/0000-0003-2442-2841)
- Haiyan Xiang
- Shengli Lai
Institutions
- Ningbo No. 2 Hospital (CN)
- Shanghai Cancer Institute (CN)
- Ningbo No.6 Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-12-12
- DOI
- https://doi.org/10.3389/fonc.2025.1652515
- Citations
- 1
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52