Tirzepatide modulates gut microbiota homeostasis to protect against diabetic kidney disease
Tirzepatide improves renal function and metabolic parameters in DKD mice through gut microbiome regulation. The underlying mechanism involves the modulation of gut-renal axis through the optimization of microbial composition, promoting the development of beneficial bacteria while inhibiting harmful microbes. These results establish a foundational understanding for the use of Tirzepatide in DKD and suggest that combined interventions targeting the gut microbiota may have potential clinical value.
Authors
- Henglu Zhang (ORCID: https://orcid.org/0000-0001-9208-3541)
- Di Yao (ORCID: https://orcid.org/0009-0005-1957-1772)
- Mengyuan Tao (ORCID: https://orcid.org/0009-0006-6799-526X)
- Weiping Lu (ORCID: https://orcid.org/0000-0002-4424-5152)
- Wencheng Zhang (ORCID: https://orcid.org/0000-0003-3730-5361)
- Li Zhou (ORCID: https://orcid.org/0000-0002-9331-0600)
- Fei Li (ORCID: https://orcid.org/0009-0006-1479-2821)
- Min Wang (ORCID: https://orcid.org/0000-0002-1252-0738)
- Ma Jun (ORCID: https://orcid.org/0009-0005-0421-369X)
- Hongman Zhang
Institutions
- Xuzhou Medical College (CN)
- Second People’s Hospital of Huai’an (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2025-12-12
- DOI
- https://doi.org/10.3389/fmolb.2025.1715024
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.81