Cetrorelix promotes cell apoptosis via the PI3K–AKT–FOXO1 pathway in epithelial ovarian cancer
These findings suggest that cetrorelix may induce EOC apoptosis via the PI3K/AKT-FOXO1 pathway, which provides mechanistic support for the therapeutic potential of GnRH antagonists in EOC management. Moreover, the identified critical regulatory pathways are prospective therapeutic targets for EOC management.
Authors
- Keqin Hua
- Meng Xie (ORCID: https://orcid.org/0000-0002-3781-779X)
- Yu Liu
- Xiaodan Zhang (ORCID: https://orcid.org/0000-0003-3827-1378)
- Ying Zhang (ORCID: https://orcid.org/0000-0003-4363-5666)
- Ning Zhang (ORCID: https://orcid.org/0000-0002-6430-4236)
Institutions
- Obstetrics and Gynecology Hospital of Fudan University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-12-12
- DOI
- https://doi.org/10.3389/fonc.2025.1631576
- Primary Topic
- FOXO transcription factor regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00