Daratumumab monotherapy in a patient with kappa light chain multiple myeloma and decompensated cirrhosis: a case report

This case underscores the critical importance of including plasma cell dyscrasias in the differential diagnosis of unexplained cirrhosis, particularly when accompanied by decreased immunoglobulin levels. The serum free light chain assay is an essential tool for facilitating a timely diagnosis. Furthermore, our findings suggest that daratumumab monotherapy can be a safe and highly effective therapeutic strategy for achieving deep, durable responses and reversing severe organ damage in patients with multiple myeloma.