Trends in mortality rates associated with multiple myeloma in the United States, 1999–2023

From 1999 to 2023, MM-related mortality in the U.S. declined overall, but substantial and persistent disparities remained by age (notably a rising burden among the oldest adults), race/ethnicity, sex, geography, and urbanization. These findings underscore the need for targeted research that links diagnosis, treatment uptake, and outcomes, and for policies to ensure equitable access to proven MM therapies so that survival gains are distributed more uniformly across all population groups.