Development of an LC-MS/MS method to quantitatively analyze escitalopram and its metabolites with application in liver and placenta microsome metabolism
A sensitive and reliable LC-MS/MS method was developed and validated for the quantitative analysis of SCT, S-DCT, and S-DDCT in RLM. Subsequently, the method was applied to the study of HLM and HPM. Incubation experiments using these microsomal systems showed that all three types of microsomes, including HPM, could metabolize SCT.
Authors
- Yujia Yang (ORCID: https://orcid.org/0000-0002-9130-7619)
- Bingyi Yao
- Chenmeizi Liang
- Xin Wang (ORCID: https://orcid.org/0000-0003-1753-2786)
- Junze Huang
- Yuanqing Guo (ORCID: https://orcid.org/0000-0002-4518-6342)
- Yifei Shen (ORCID: https://orcid.org/0000-0001-7174-4793)
- Yuanjin Zhang
Institutions
- Shanghai Changning Maternity and Infant Health Hospital (CN)
- East China Normal University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-12-12
- DOI
- https://doi.org/10.3389/fphar.2025.1714686
- Primary Topic
- Hypothalamic control of reproductive hormones
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- East China Normal University