Low complement items play different roles on the classification performance of SLICC-2012, EULAR/ACR-2019, and SLERPI
The low complement item strongly improved the sensitivity and early classification capacity of SLICC-2012 while minimally influencing SLERPI. Furthermore, higher weights assigned to combined low C3 and C4 levels in EULAR/ACR-2019 appear clinically justified.
Authors
- Leixi Xue (ORCID: https://orcid.org/0000-0001-8415-7088)
- Siping Li (ORCID: https://orcid.org/0000-0002-8049-6979)
- Shanshan Chen (ORCID: https://orcid.org/0000-0001-9723-2403)
- Mengxue Yan
- Lin Zhang (ORCID: https://orcid.org/0000-0002-0663-478X)
- Mei Tang
Institutions
- Soochow University (CN)
- Wuxi Municipal Health Bureau (CN)
- Second Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-12-12
- DOI
- https://doi.org/10.3389/fmed.2025.1695383
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00