CSF-flow prior and after spinal tap test in patients with idiopathic normal pressure hydrocephalus—an exploratory study using real-time phase-contrast MRI
RT-PC MRI provides a promising, non-invasive approach for evaluating CSF-flow in iNPH. Baseline CSF-flow volumes were elevated in the inner ventricular system, particularly in the third ventricle, and correlated with ventricular enlargement, suggesting that increased CSF-flow may reflect disease progression rather than therapeutic response. However, in contrast to clinical tests, the lack of change of CSF-flow after STT limits its utility for patient selection for ventriculo-peritoneal-shunt implantation.
Authors
- Jan Liman (ORCID: https://orcid.org/0000-0002-7465-9655)
- Ilko Maier (ORCID: https://orcid.org/0000-0001-6988-8878)
- Sabine Hofer (ORCID: https://orcid.org/0000-0003-4986-3539)
- Veit Rohde (ORCID: https://orcid.org/0000-0003-3014-4307)
- Marielle Heide
- Christian von der Brelie (ORCID: https://orcid.org/0000-0003-4912-2917)
- Fiona Dierksen (ORCID: https://orcid.org/0009-0004-1913-0603)
- Mathias Bähr (ORCID: https://orcid.org/0000-0001-6242-5299)
- Peter Dechent (ORCID: https://orcid.org/0009-0006-4005-3352)
- Felix Bernsdorff
Institutions
- Paracelsus Medizinische Privatuniversität (DE)
- Universitätsmedizin Göttingen (DE)
- Johanniter-Krankenhaus Bonn (DE)
Publication Details
- Journal
- Frontiers in Neuroimaging
- Published
- 2025-12-12
- DOI
- https://doi.org/10.3389/fnimg.2025.1665687
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00