S1PR3 Inhibition in alveolar epithelial cells alleviates pulmonary fibrosis by enhancing alveolar barrier function
S1PR3 in alveolar epithelial cells plays a critical role in maintaining alveolar-capillary barrier integrity during pulmonary fibrosis. Targeted inhibition of S1PR3 strengthens tight junctions and alleviates inflammation, suggesting that S1PR3 may serve as a promising therapeutic target for PF.
Authors
- Jing Jin (ORCID: https://orcid.org/0000-0003-3478-1610)
- M Q Wang (ORCID: https://orcid.org/0009-0003-2513-4662)
- Mengyao Hao (ORCID: https://orcid.org/0000-0002-0614-3948)
- Guodong Tang
- En‐Min Zhou (ORCID: https://orcid.org/0000-0001-8942-013X)
- Huimin Jiang (ORCID: https://orcid.org/0009-0004-5239-2752)
- Rong Fu (ORCID: https://orcid.org/0000-0002-9928-9224)
- Xiaoguang Chen (ORCID: https://orcid.org/0000-0003-2035-4431)
- Li‐Ping Bai (ORCID: https://orcid.org/0000-0002-2806-6883)
- Xiaoxi Lv
Institutions
- Macau University of Science and Technology (MO)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1186/s12931-025-03435-y
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00