Macrophage adaptation to hypoxia: metabolism, migration, and phagocytosis
These findings highlight the plasticity of macrophages in adapting to low-oxygen environments and underscore their potential role in host defense and inflammation resolution in periodontal disease. The modulation of these responses may inform novel therapeutic approaches targeting hypoxia-associated immune dysfunction.
Authors
- Gésinda I. Geertsema-Doornbusch
- Lu Yuan (ORCID: https://orcid.org/0000-0001-5923-1581)
- Henny C. van der Mei
- Tiemen Mellema
Institutions
- University Medical Center Groningen (NL)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-12-12
- DOI
- https://doi.org/10.3389/fcimb.2025.1706664
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- HORIZON EUROPE Framework Programme