A proteomic profile correlates with salivary gland inflammation and disease-associated antibodies in Sjögren’s disease

We define a validated serum proteomic signature that reflects local glandular inflammation and correlates with genetic and serological features. The 'Sjögren protein score' holds promise as a noninvasive biomarker for the diagnosis of SjD.

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Publication Details

Journal
Annals of the Rheumatic Diseases
Published
2025-12-12
DOI
https://doi.org/10.1016/j.ard.2025.11.013
Primary Topic
Salivary Gland Disorders and Functions
Type
article
Field-Weighted Citation Impact
0.00

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article

A proteomic profile correlates with salivary gland inflammation and disease-associated antibodies in Sjögren’s disease

Sara Magnusson Bucher, Malin V. Jonsson, Juliana Imgenberg‐Kreuz, Elina Richardsdotter Andersson et al.
Annals of the Rheumatic Diseases
Salivary Gland Disorders and Functions
article

A proteomic profile correlates with salivary gland inflammation and disease-associated antibodies in Sjögren’s disease

Sara Magnusson Bucher, Malin V. Jonsson, Juliana Imgenberg‐Kreuz, Elina Richardsdotter Andersson, Silke Appel, Marie Fischer, Per Eriksson, Gunnel Nordmark, Katrine Brække Norheim, Lauro Meneghel, Marie Wahren‐Herlenius, Elisabeth Mæland, Marika Kvarnström, Helena Forsblad‐d’Elia, Peter Olsson, Ingrid Skelton Kockum, Roland Jonsson, Kathrine Skarstein, Johannes Mofors, Daniel Hammenfors, Roald Omdal, Thomas Mandl, Albin Björk, Svein Joar Auglænd Johnsen
article en

Abstract

We define a validated serum proteomic signature that reflects local glandular inflammation and correlates with genetic and serological features. The 'Sjögren protein score' holds promise as a noninvasive biomarker for the diagnosis of SjD.

Annals of the Rheumatic DiseasesVol. 85(2)
Linköping University (SE), Uppsala University (SE), Karolinska University Hospital (SE), Lund University (SE), Örebro University (SE), Stavanger University Hospital (NO), Science for Life Laboratory (SE), Haukeland University Hospital (NO), Karolinska Institutet (SE), University of Bergen (NO), University of Gothenburg (SE)
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Openalex Percentile: Top 51%
Salivary Gland Disorders and Functions
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