Perirenal fat and alcohol consumption contribute to marginal bone loss after dental implant surgery in type 2 diabetes

We read with great interest the article by Li <i>et al</i>, reporting an observational study on the inflammatory response-mediated bone loss after dental implant surgery in patients with type 2 diabetes mellitus (T2DM). This study provides relevant information for reducing the risk of peri-implantitis after dental implant surgery in T2DM, highlighting the need to bridge the gap between risk identification and effective clinical management. However, the complex etiopathogenetic mechanisms elucidating the association between elevated inflammatory response markers and marginal bone loss in T2DM are not sufficiently clarified. Recent studies suggest that perirenal adipose tissue and alcohol consumption affect bone metabolism, which may contribute to the observed marginal bone loss after dental implant surgery in T2DM. Therefore, further studies using state-of-the-art bone-assessing methodologies are needed to enhance our understanding of the potential covariant effects of perirenal adipose tissue and alcohol consumption on inflammatory response-mediated bone loss after dental implant surgery in T2DM.