Methylation status of leptin gene promoter in relatively lean Chinese adults with prediabetes and type 2 diabetes mellitus
LEP promoter hypomethylation parallels worsening glycemic status in lean Chinese adults, suggesting its potential as a blood-based epigenetic biomarker for diabetes progression, pending validation in longitudinal cohorts.
Authors
- Shiqi Sun (ORCID: https://orcid.org/0009-0009-7257-7996)
- Qi Huang (ORCID: https://orcid.org/0000-0002-0261-4562)
- Shijie Liang (ORCID: https://orcid.org/0000-0003-0890-7435)
- Jiazhong Sun (ORCID: https://orcid.org/0009-0001-4319-9756)
Institutions
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
Publication Details
- Journal
- World Journal of Diabetes
- Published
- 2025-12-12
- DOI
- https://doi.org/10.4239/wjd.v16.i12.112789
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 0.00