A Multi-PTM omics atlas uncovers novel aging regulators in colorectal cancer
This study presents the first integrative network map of aging regulation in CRC based on multiple PTMs. Notably, hub proteins such as LMNB1 have emerged as key regulatory targets. These findings provide a theoretical foundation for the development of aging-cancer axis-related biomarkers and therapeutic strategies for CRC.
Authors
- Jie Du (ORCID: https://orcid.org/0000-0003-2821-2497)
- Yong Dai (ORCID: https://orcid.org/0000-0002-6840-9158)
- Yujie Zhang
- Tianyuan Li (ORCID: https://orcid.org/0000-0002-6187-3580)
- Min Feng (ORCID: https://orcid.org/0000-0001-9801-650X)
- Wei Zhang (ORCID: https://orcid.org/0000-0003-2255-5405)
- Feng Zhu (ORCID: https://orcid.org/0000-0002-3408-6717)
- Ergeng Hao
Institutions
- Anhui University of Science and Technology (CN)
- Peking University Shenzhen Hospital (CN)
- Guangdong Province Environmental Monitoring Center (CN)
- Guangdong Provincial Center for Disease Control and Prevention (CN)
- Guangdong Provincial People's Hospital (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1186/s12885-025-15274-7
- Citations
- 1
- Primary Topic
- Protein Tyrosine Phosphatases
- Type
- article
- Field-Weighted Citation Impact
- 0.81