HMGCR-related SNPs and cholelithiasis: statins may exert effects beyond lipid-lowering
These facts shows that statins are associated with a decreased risk of cholelithiasis, and this association is unlikely to be mediated by lipid-lowering effects. Further clinical trials and basic experimental validation is needed to validate their relationship and underlying mechanisms.
Authors
- Shiyu Du (ORCID: https://orcid.org/0000-0002-5482-2240)
- Qilu Wei (ORCID: https://orcid.org/0000-0002-5366-7584)
- Da Qin (ORCID: https://orcid.org/0000-0001-9725-2244)
Institutions
- China-Japan Friendship Hospital (CN)
Publication Details
- Journal
- Postgraduate Medical Journal
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1093/postmj/qgaf222
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00