Cannabidiol does not cause DNA double-strand breaks in a human liver-derived cell model
In our model, CBD stimulated the cells, as confirmed by modulation of CB2 expression as well as changes in intracellular cAMP. Our results show that CBD in ranges between 5 [Formula: see text] to 50 [Formula: see text] does not significantly increase the amount of DNA double strand breaks in HepG2 cells compared to the control. However, we did observe a significant reduction in cell proliferation and a significant increase in intracellular cAMP levels following CBD treatment.
Authors
- Victoria Liedtke (ORCID: https://orcid.org/0000-0001-7838-5818)
- Romano Weiss (ORCID: https://orcid.org/0000-0002-1267-6249)
- Stefan Rödiger (ORCID: https://orcid.org/0000-0002-1441-6512)
Institutions
- Brandenburg University of Technology Cottbus-Senftenberg (DE)
Publication Details
- Journal
- Journal of Cannabis Research
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1186/s42238-025-00365-w
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00