CD248, targeted by veratramine and neobavaisoflavone, mediates pathological changes of renal tubular epithelial cells induced by high glucose
CD248 participates in HG-induced EMT of renal tubular epithelial cells and renal fibrosis by regulating TGF-β1/Smads pathway, and VER and NBIF are two potential natural drugs which targets it to ameliorate DN.
Authors
- Nan Hu (ORCID: https://orcid.org/0009-0005-2565-0362)
- Xinzhou Zhang (ORCID: https://orcid.org/0000-0003-1082-2625)
- Ping Li (ORCID: https://orcid.org/0000-0002-4549-9517)
- Zhen Wang (ORCID: https://orcid.org/0000-0002-6377-3890)
- Dan Song (ORCID: https://orcid.org/0000-0003-1594-7662)
- Mei Lin
Institutions
- Southern University of Science and Technology (CN)
- ShenZhen People’s Hospital (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Hereditas
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1186/s41065-025-00624-z
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00