CXCR3 gene as a therapeutic target in colorectal cancer

Our findings suggest that downregulation of CXCR3 mRNA inhibits colorectal cancer cell growth through inhibition of the AKT‒mTOR pathway. The CXCR3 receptor can be considered a new therapeutic target in colorectal cancer therapy.

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Publication Details

Journal
BMC Cancer
Published
2025-12-12
DOI
https://doi.org/10.1186/s12885-025-15409-w
Primary Topic
Chemokine receptors and signaling
Type
article
Field-Weighted Citation Impact
0.00
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article

CXCR3 gene as a therapeutic target in colorectal cancer

Mohammad Malmir, Seyedeh Zohreh Azarshin, Seyedeh Fatemeh Sajjadi, Mehrdad Behmanesh
BMC Cancer
Chemokine receptors and signaling
article

CXCR3 gene as a therapeutic target in colorectal cancer

Mohammad Malmir, Seyedeh Zohreh Azarshin, Seyedeh Fatemeh Sajjadi, Mehrdad Behmanesh
article en

Abstract

Our findings suggest that downregulation of CXCR3 mRNA inhibits colorectal cancer cell growth through inhibition of the AKT‒mTOR pathway. The CXCR3 receptor can be considered a new therapeutic target in colorectal cancer therapy.

BMC CancerVol. 26(1)
Tarbiat Modares University (IR)
Openalex Percentile: Top 45%
Chemokine receptors and signaling
DOIOpen Access PDFOpenAlex
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CXCR3 gene as a therapeutic target in colorectal cancer — Mohammad Malmir, Seyedeh Zohreh Azarshin, et al. · BMC Cancer (2025) | TGRS Research Map | TGRS