N-acetylglucosamine facilitates coordinated flow-like movement of myoblasts, forming a foundation for efficient myogenesis
Our findings suggest that GlcNAc, in conjunction with Gal-3, enhances myotube formation by fostering an environment conducive to myoblast positioning, establishing optimal coordinated flow-like movement, and facilitating fusion. This suggests potential therapeutic applications of GlcNAc in muscle repair and muscle disorders.
Authors
- Guillaume St‐Pierre
- Masahiko S. Satoh (ORCID: https://orcid.org/0000-0002-0461-2296)
- Sachiko Sato (ORCID: https://orcid.org/0000-0002-5960-1703)
- Ann Rancourt (ORCID: https://orcid.org/0000-0002-5740-5506)
- Kazuki Nakajima (ORCID: https://orcid.org/0000-0003-1986-0150)
- Elizabeth Bouchard
- Kana Hagiwara
- Maude Fillion
Institutions
- Gifu University (JP)
- Université Laval (CA)
Publication Details
- Journal
- Skeletal Muscle
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1186/s13395-025-00404-3
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00