Circulating tumor cells predict relapse in head and neck mucosal squamous cell carcinoma
CTCs detected using the AccuCyte-CyteFinder platform demonstrate independent prognostic value in HNmSCC patients, complementing conventional pathologic assessment, particularly margin involvement. This proof-of-concept study provides preliminary evidence that preoperative CTC enumeration could enhance risk stratification to identify patients at high risk of relapse, potentially enabling more personalised surveillance and treatments.
Authors
- James Wykes (ORCID: https://orcid.org/0000-0002-2956-0453)
- Carsten E. Palme (ORCID: https://orcid.org/0000-0002-3172-7275)
- Xiaoqi Liang (ORCID: https://orcid.org/0009-0004-9625-1441)
- Masako Dunn (ORCID: https://orcid.org/0000-0001-6379-2621)
- Jean Yang (ORCID: https://orcid.org/0000-0002-5271-2603)
- Ruta Gupta
- John E.J. Rasko (ORCID: https://orcid.org/0000-0003-2975-807X)
- Dannel Yeo (ORCID: https://orcid.org/0000-0002-6546-1209)
- Veronica Cheung (ORCID: https://orcid.org/0000-0002-2993-6457)
- Tsu‐Hui Low (ORCID: https://orcid.org/0000-0001-8958-736X)
- Heidi Strauss
- Fawaz Mayez Mahfouz
- Althea Bastian
- Grace Lim
- Jenny Lee (ORCID: https://orcid.org/0000-0001-8844-3444)
- Jonathan R. Clark (ORCID: https://orcid.org/0000-0003-1209-772X)
- Saima Siddiqui (ORCID: https://orcid.org/0000-0003-3020-0233)
Institutions
- The University of Sydney (AU)
- New South Wales Department of Health (AU)
- Royal Prince Alfred Hospital (AU)
- Centenary Institute (AU)
- UNSW Sydney (AU)
- Chris O’Brien Lifehouse (AU)
Publication Details
- Journal
- European Journal of Surgical Oncology
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1016/j.ejso.2025.111357
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00