Exploring Cuproptosis: New Biomarkers and Therapeutic Targets for Skin Diseases

Copper, an essential trace element, plays a critical role in numerous physiological processes, including melanin synthesis, antioxidant defense, and wound healing. However, recent studies have revealed a concerning issue: excessive copper accumulation exerts cytotoxic effects and induces a newly identified form of cell death—cuproptosis. This mechanism is closely linked to the onset and progression of various skin diseases, including psoriasis, melanoma, and keloids. These findings provide a new perspective for the study and treatment of skin diseases. However, the specific molecular mechanisms linking cuproptosis to dermatologic disorders remain insufficiently understood. To address this gap, this review aimed to summarize current evidence on the role of cuproptosis in skin diseases, clarify its underlying biological mechanisms, and discuss its potential clinical and therapeutic implications.