Longitudinal [18F]LW223 PET imaging of macrophage-driven inflammation following myocardial infarction in a rat model: implications for left ventricular remodelling
[<sup>18</sup>F]LW223 identifies a persistent and predominantly macrophage-driven inflammatory response with early [<sup>18</sup>F]LW223 infarct binding associated with later cardiac dysfunction.
Authors
- Andrew Sutherland (ORCID: https://orcid.org/0000-0001-7907-5766)
- Lachlan J. N. Waddell (ORCID: https://orcid.org/0000-0001-6299-2904)
- Thomas M. Wishart (ORCID: https://orcid.org/0000-0002-1973-6654)
- Ana Clara Juan De Albuquerque
- Judit Aguilar Martí
- Sally L. Pimlott (ORCID: https://orcid.org/0000-0002-8396-3392)
- Nicholas L. Mills (ORCID: https://orcid.org/0000-0003-0533-7991)
- Agne Knyzeliene
- Dominic Kurian (ORCID: https://orcid.org/0000-0002-5924-665X)
- Mark G. MacAskill (ORCID: https://orcid.org/0000-0001-5355-3109)
- Timaeus E. F. Morgan (ORCID: https://orcid.org/0000-0003-0220-8879)
- Carlos J. Alcaide‐Corral (ORCID: https://orcid.org/0000-0002-3002-0649)
- Christophe Lucatelli (ORCID: https://orcid.org/0000-0001-9866-7257)
- Adriana Tavares (ORCID: https://orcid.org/0000-0001-7505-9144)
- Adrian Thomson (ORCID: https://orcid.org/0000-0001-7320-300X)
- Marc R. Dweck (ORCID: https://orcid.org/0000-0001-9847-5917)
- Takeshi Fujisawa (ORCID: https://orcid.org/0000-0002-6627-3218)
- E. Chui (ORCID: https://orcid.org/0000-0001-8730-8654)
- David E. Newby (ORCID: https://orcid.org/0000-0001-7971-4628)
- Catriona Wimberley (ORCID: https://orcid.org/0000-0002-2709-6837)
- Viktória Balogh
- Victoria J. M. Reid (ORCID: https://orcid.org/0009-0002-7138-5027)
Institutions
- Roslin Institute (GB)
- NHS Greater Glasgow and Clyde (GB)
- Institute of Particle Physics (CA)
- Nottingham Trent University (GB)
- University of Glasgow (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1007/s00259-025-07691-4
- Citations
- 1
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- British Heart Foundation