Prevention of Cholestatic Liver Disease Through BCL6-FXR Enterohepatic Crosstalk
These findings identify BCL6 as a previously unrecognized integrator of FXR-mediated enterohepatic signaling and a critical regulator of BA metabolism, acting through both FXR-dependent and FXR-independent mechanisms to maintain BA homeostasis and protect the liver from BA-induced injury.
Authors
- Kristine Yarnoff (ORCID: https://orcid.org/0000-0002-3442-8326)
- Meredith A. Sommars
- Ellen Fruzyna (ORCID: https://orcid.org/0000-0002-6902-2078)
- Richard M. Green
- Janice C. Wang (ORCID: https://orcid.org/0000-0001-8669-9681)
- Christopher R. Futtner (ORCID: https://orcid.org/0000-0003-3004-9983)
- Grant D. Barish (ORCID: https://orcid.org/0000-0001-8753-0546)
- Yasushi Omura
Institutions
- Northwestern University (US)
- Jesse Brown VA Medical Center (US)
- Wheaton College - Illinois (US)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101706
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00