DOCK10 Regulates Insulin Hypersecretion in Insulinoma and Serves as a Diagnostic and Therapeutic Target
This study suggests that DOCK10 may serve as a diagnostic marker for insulin-secreting lesions and a potential therapeutic target in insulinoma. It provides mechanistic insights that may inform future strategies for precision diagnostics and treatment of functional pancreatic neuroendocrine tumors.
Authors
- Keiichi Akahoshi (ORCID: https://orcid.org/0000-0003-3792-5659)
- Daisuke Ban (ORCID: https://orcid.org/0000-0003-0868-8519)
- Go Ito (ORCID: https://orcid.org/0009-0004-7488-0335)
- Akira Ito
- Daisuke Asano (ORCID: https://orcid.org/0000-0002-0867-7572)
- Takashi Muto (ORCID: https://orcid.org/0000-0003-1988-6983)
- Masanori Kobayashi (ORCID: https://orcid.org/0000-0003-4045-3103)
- Yoshihito Kano (ORCID: https://orcid.org/0000-0001-7511-7009)
- Joana Pimenta Bernardes
- Atsushi Kudo
- Mamoru Watanabe
- Hironari Yamashita
- Yoshiya Ishikawa (ORCID: https://orcid.org/0000-0002-3348-5652)
- Yui Hiraguri
- Hiromune Katsuda (ORCID: https://orcid.org/0000-0002-3863-2703)
- Philip Rosenstiel (ORCID: https://orcid.org/0000-0002-9692-8828)
- Yuko Kinowaki (ORCID: https://orcid.org/0000-0001-8907-2569)
- Satoru Fujii (ORCID: https://orcid.org/0000-0002-9122-0150)
- Ryuichi Okamoto (ORCID: https://orcid.org/0000-0002-7047-571X)
- Shiro Yui (ORCID: https://orcid.org/0000-0003-4268-647X)
- Eriko Katsuta (ORCID: https://orcid.org/0000-0001-5862-2919)
- François Kimmig (ORCID: https://orcid.org/0000-0001-9680-502X)
- Yasuhiro Asahina (ORCID: https://orcid.org/0000-0002-9900-0064)
- Stefan Schreiber
- Neha Mishra (ORCID: https://orcid.org/0000-0002-6776-2195)
- Hiroki Ueda (ORCID: https://orcid.org/0009-0001-3352-7808)
- Yasuhiro Nemoto
- T Shin
- Masato Miyoshi
Institutions
- Tokyo Institute of Technology (JP)
- Christian-Albrechts-Universität zu Kiel (DE)
- Juntendo University (JP)
- Tokyo Institute of Psychiatry (JP)
- Tokyo Metropolitan Institute of Medical Science (JP)
- University Hospital Schleswig-Holstein (DE)
- Institute for Health Economics and Policy (JP)
- Jiangsu Province Institute of Quality & Safety Engineering (CN)
- Institute of Science Tokyo (JP)
- University of Lübeck (DE)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101705
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.00