Efficient Dibromination of Aromatics with Fe(NO3)3·9H2O/FeBr3
Abstract A simple, efficient, and environmentally friendly methodology for the dibromination of anisoles using Fe(NO3)3·9H2O/FeBr3 at room temperature was developed. In general, anisoles bearing electron-donating or weak electron-withdrawing groups gave the dibrominated product in good to excellent yields, while anisoles bearing a strong electron-withdrawing group gave a high yield of the monobromination product. This protocol was also suitable for the bromination of 2- or 4-substituted substrates. Importantly, this protocol was also applicable for gram-scale synthesis. It is hopeful that this methodology will have great use in organic synthesis.
Authors
- Yiying Li (ORCID: https://orcid.org/0000-0003-3566-6008)
- Huanjun Xu (ORCID: https://orcid.org/0000-0002-2704-5108)
- Caicui Li
- Jinhui Wang (ORCID: https://orcid.org/0000-0003-3201-707X)
- Xiaodan Wang (ORCID: https://orcid.org/0000-0003-0216-5135)
- Lijuan Wang (ORCID: https://orcid.org/0000-0002-1288-155X)
- Xinmei Wang (ORCID: https://orcid.org/0009-0002-2131-5741)
- Wang-Rong Yang (ORCID: https://orcid.org/0000-0003-3470-3639)
- Zhaoyan Huang (ORCID: https://orcid.org/0009-0000-4192-1760)
- Wubo Wan
Institutions
- Hainan Normal University (CN)
- Harbin Medical University (CN)
- Qiongtai Teachers College (CN)
- Hainan Medical University (CN)
- Hainan Tropical Ocean University (CN)
Publication Details
- Journal
- SynOpen
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1055/a-2769-2826
- Primary Topic
- Vanadium and Halogenation Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China