Association of accelerated biological aging and frailty with the risk of severe infection: a prospective study in the UK Biobank
Accelerated biological aging and frailty were significantly associated with increased risks of overall and type-specific severe infections. These findings suggest that integrating biological aging assessments into routine healthcare could improve infection risk stratification and guide targeted prevention strategies.
Authors
- Guoyou Qin
- Yifang Huang (ORCID: https://orcid.org/0009-0008-4643-7730)
- Zixuan Jiang (ORCID: https://orcid.org/0000-0001-6180-6487)
- Yongfu Yu
- Chen Huang (ORCID: https://orcid.org/0000-0002-7092-7587)
- Jing Wang (ORCID: https://orcid.org/0000-0003-2891-670X)
- Lulu Pan (ORCID: https://orcid.org/0000-0001-7724-9240)
- Xueying Zheng (ORCID: https://orcid.org/0000-0003-4123-9643)
- R. Bai (ORCID: https://orcid.org/0009-0007-9213-9059)
- Qing-qing Li
Institutions
- Harbin Medical University (CN)
- Fudan University (CN)
- Daqing City People's Hospital (CN)
- Shanghai Public Health Clinical Center (CN)
- Ministry of Education (KR)
Publication Details
- Journal
- The Journal of Frailty & Aging
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1016/j.tjfa.2025.100118
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 0.00