The combined treatment with TOP-V122, a dual-acting NO-releasing PDE-5 inhibitor, and ionizing irradiation as a novel therapeutical strategy for colorectal carcinoma
The PDE-5 inhibitor TOP-V122 represents a novel therapeutic option for colorectal cancer alone and in combination with radiotherapy.
Authors
- Irene Vetrugno (ORCID: https://orcid.org/0009-0003-5297-8879)
- Reto Naef (ORCID: https://orcid.org/0000-0002-7768-6026)
- Enni Markkanen (ORCID: https://orcid.org/0000-0001-7780-8233)
- Claire Beckers (ORCID: https://orcid.org/0000-0003-4678-6865)
- Chantal Pauli (ORCID: https://orcid.org/0000-0001-9621-8511)
- Martin Pruschy (ORCID: https://orcid.org/0000-0002-3124-9015)
- Lazaros Vasilikos (ORCID: https://orcid.org/0000-0003-4071-7025)
- Esra Lone- Kapaklikaya
- Zuzana Garajovà
- Tobias Braun (ORCID: https://orcid.org/0000-0001-7987-0225)
- Hermann Tenor (ORCID: https://orcid.org/0009-0007-8406-1431)
- Alba Sánchez‐Fernández
- Yoshita Bhide
Institutions
- University of Zurich (CH)
- University Hospital of Zurich (CH)
Publication Details
- Journal
- Radiotherapy and Oncology
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1016/j.radonc.2025.111331
- Primary Topic
- Phosphodiesterase function and regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00