Decreased endothelial cell retinoic acid signaling accelerates progression of single ventricle pulmonary arteriovenous malformations
In this study, we report the novel application of scRNAseq to study mechanisms underlying single ventricle PAVMs in a surgical rat model. We identified multiple dysregulated biological processes in rat lung ECs post-Glenn, including decreased ATRA signaling and conserved gene expression patterns with HHT. Dietary modification of Vit A intake altered post-Glenn shunting and represents a novel potential therapeutic strategy for single ventricle PAVMs and HHT AVMs.
Authors
- Jaime Wendt Andrae
- Henry Rousseau
- Stryder M. Meadows (ORCID: https://orcid.org/0000-0003-0968-7155)
- Nam Q. Nguyen (ORCID: https://orcid.org/0000-0002-1270-5441)
- Angela Mathison (ORCID: https://orcid.org/0000-0002-6763-2710)
- Xingyan Zhou (ORCID: https://orcid.org/0000-0001-7614-384X)
- Igor Shmarakov (ORCID: https://orcid.org/0000-0002-4073-9585)
- Michael Tschannen
- Victor X. Jin (ORCID: https://orcid.org/0000-0002-8765-3471)
- Tina C. Wan (ORCID: https://orcid.org/0000-0001-6643-4678)
- Ramani Ramchandran (ORCID: https://orcid.org/0000-0002-3555-6119)
- Amy Pan (ORCID: https://orcid.org/0000-0002-7199-7704)
- Andrew D. Spearman (ORCID: https://orcid.org/0000-0003-2035-5258)
- Olivia Groh
Institutions
- Rutgers, The State University of New Jersey (US)
- Tulane University (US)
- Children's Hospital of Wisconsin (US)
- Medical College of Wisconsin (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2025-12-11
- DOI
- https://doi.org/10.64898/2025.12.08.693095
- Primary Topic
- Vascular Anomalies and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00