Impact of Oral Semaglutide on Kidney Outcomes in People With Type 2 Diabetes: Results From the SOUL Randomized Trial

In people with T2D and ASCVD and/or CKD but with overall mostly preserved eGFR, orally administered semaglutide, compared with placebo, did not significantly reduce adverse kidney outcomes but did slow the decline in eGFR.

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Journal
Diabetes Care
Published
2025-12-04
DOI
https://doi.org/10.2337/dc25-1080
Citations
1
Primary Topic
Diabetes Treatment and Management
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article
Field-Weighted Citation Impact
1.29

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article

Impact of Oral Semaglutide on Kidney Outcomes in People With Type 2 Diabetes: Results From the SOUL Randomized Trial

S. E. Inzucchi, A. Idogaki, Nebojša Lalić, M. Husain et al.
1 citations
Diabetes Care
Diabetes Treatment and Management
1.29
article

Impact of Oral Semaglutide on Kidney Outcomes in People With Type 2 Diabetes: Results From the SOUL Randomized Trial

S. E. Inzucchi, A. Idogaki, Nebojša Lalić, M. Husain, Mihaela-Magdalena Busegeanu, E.J. Abbink-Zandbergen, Melissa M. Esser, Agostino Consoli, G. Kees Hovingh, Per Schelde, Bruno Lapauw, Snežana Polovina, Samer Nakhle, І. P. Kaydashev, Silvio E. Inzucchi, Alena Šmahelová, Priyamvada Singh, M. Joshi, M. Jebbink, Mariano Chahin, Osamu Ebisui, E. Setola, A. García Quintana, Alice Larroumet, Jobin John Jacob, X. Ye, J. Lacka, Hajira B Bacus, C.-N. Huang, K. Cerna, Thorsten Koch, Hiroshige Jinnouchi, Jaeryang Chu, Richard Tytus, Mark Warren, Trevenesan Padayachee, J.F. Thuan, R. E. Pratley, HIROSHI DOMAE, D. R. Mikkelsen, Dragan Dimić, Guy Tellier, Amit Dang, Andreas L. Birkenfeld, Nor Hamdan Mohamad Yahaya, N. Thomas, Harold W. de Valk, Linong Ji, Danijela Tatović, J Lüdemann, Алексей Вадимович Зилов, Michael Jardula, Zubin Punthakee, Isamu Mizote, Apiradee Sriwijitkamol, Francis Duyck, Ankur Doshi, О.T. Oleksyk, Carmen Crișan, Anthony Gunstone, Srecko Tusek, Rodica Pop‐Busui, Mayur B. Patel, D. Weiss, R. C. W., C. Montalbán Carrasco, Sekhar P. Reddy, Ömür Tabak, Sun-Ja Choi, Nikolaus Marx, N. Rasouli, Kalpana Singh, Aleksandar Djukić, T. Pieber, Jie Liu, Manoj S Chawla, Augustin C. Moţ, P. Buranasupkajorn, Søren Gregersen, Valeria Visco, M. J. Budoff, Rosario Arechavaleta, Martin Haluzı́k, Masahiro Igarashi, A.V. Ignatyeva, P. Nicol, Supawan Buranapin, Sharon L. Mulvagh, E. Fließer-Görzer, Naveen Mittal, Joseph Mancini, Gabriela Román, Ulrik Pedersen‐Bjergaard, Gian Paolo Fadini, Ignacio MacKinnon, Patrick English, P. Fasching, John Agaiby, Ronald G. García, Anuj Bhargava, K. Astamirova, Shao-Chia Chen, S.A.N.T. Landewé-Cleuren, A. Philis-Tsimikas, John A. Poremba, Fang Tan, Tiven Marwah, Silvija Canecki-Varžić, Atsushi Sueyoshi, Giuseppe Murdolo, Eun Seok Kang, J. Kesavadev, Chandrajit Bajaj, Wookjin Lee, Genya Aharon‐Hananel, S Nagelberg, К. Ю. Маляр, Christophe De Block, F. Oh, Brian D. Snyder, N. Tandon, Gilbert Ledesma, Radovan Plášil, Viswanathan Mohan, Gongsheng Yuan, L. Kargina, Juraj Gmitrov, João Eduardo Nunes Salles, K. Sivalingam, Dipesh Patel, J. Rosenstock, J. Francisco, Kathleen Mullan Harris, Tira Chaicha-Brom, Sanja Beca, Andrew Kernohan, A. Park, John Eric Deanfield, Peter Gagianas, Chul‐min Lee, A. Pradignac, Joseph Risser, John B. Buse, Davide Lauro, Rakesh Sahay, Jan Culak, Subir Ray, Esubalew Tesfahun Ayele, Michael Gilbert, Veronica Anghel, Federico Pérez Manghi, Sushela Chaidarun, Avishai M. Tsur, Kazushige Hanaoka, B. Saboo, Ankur R. Desai, Louis A.G. Lieverse, Johannes F.E. Mann, S. G. Kim, Hirotaka Watada, Ibeth Erazo, Tristin Chaudhury, D. Black, Jaipaul Singh, Luiz Alberto Andreotti Turatti, Francesco Andreozzi, Jelena Vučak Lončar, K. Hoogenberg, Enrique C. Morales Villegas, Mehmet Koçak, Ntobeko Ntusi, Amir Tirosh, Adriaan Kooy, Teodora Beljić Živković, Denise Reis Franco, R. Roginski Rea, A. Ola Odugbesan, Danijela Fabris Vitković, R. I. Fink, Masafumi Doi, Anne Monier, Alina Nicoara, S. T. Zyangirova, O. Ya. Mishchenko, Thomas van Bemmel, Harpal Randeva, Qasim Bhorat, Daniel M. Johnson, Cristóbal Morales, Alina Urbanovych, Roberta Marques Lisboa, Jan Vrkoč, Charles Fogarty, Silvio Buscemi, Harold Edward Bays, Roberta Lupoli, Hans‐Peter Kempe, Fettah Acıbucu, Katherine Connelly, John Weisnagel, Javier Delgado‐Lista, Benjamin Gaborit, Gerd Kahrmann, Prin Vathesatogkit, Rohana Abdul Ghani, Ole Kleist Jeppesen, Neeru P Aggarwal, Xinzhong Dong, Nikhil Bhagwat, Dragana Lovre, I. J. Tandron, Lubna Mirza, Olga A. Zagrebelnaya, Chaicharn Deerochanawong, Kenneth Egstrup, Henry Traylor, Y. Kadam, Sunun Benjachareonwong, Puntip Tantiwong, Daniel Piskorz, Shuji Nakamura, Dalibor Sosovec, Michael Lillestol, Alok Kumar Kanungo, B. Vergès, Raman Purighalla, Sam Philip, Francisco José Tinahones, Mary Seeber, Jeyakantha Ratnasingam, Thozhukat Sathyapalan, Deepak Lakha, Louis Potier, Jitka Zemanová, Alsu Gafurovna Zalevskaya, Alberto Lorenzatti, J Schulze, José M Pozzi, John McKnight, George Mitchell Cornett, Rajesh Chawla, Ana Cristina García Ulloa, Hitasha Bajaj, Rattana Leelawattana, I. Lingvay, R. A. JACKSON, Laura J. Rose, Daniël H. van Raalte, Barış Sarıakçalı, Alper Sönmez, E. Cantu, Ilan Shimon, Christine P Oldenburg-Ligtenberg, Ivan Kruljac, K. Dhatariya, Irina Filip, Aslam Amod, Carolina Lúquez, A. Kiyosue, Jordi Mesa, Hani Al‐Asaad, KM Suryanarayana, А. Б. Песков, Takeshi Osonoi, Amir Bashkin, Thomas Schaum, Carl Wierum, MONIKA KELLERER, T. V. Saprina, Christoph Ebenbichler, Sumiko Fujino, Márcio Vidotti, J. Condit, Darren K. McGuire, Neil R Poulter, Robert S. Lindsay, N.V. Pashkovska, Leyla Gaysina, T. Murakami, K. Cannon, Shalini Jain, James Thrasher, Pradeep Joshi, R. H. Chochinov, Iryna Bondarets, Shih‐Te Tu, Vivek Awasty, Arisara Suwanagool, Silmara Leite, Juan José Gorgojo Martínez, Fahrı Bayram, P Kyselová, Syed Shahzad Hasan, Ayano Oiwa, Shichun Bao, Cyrus Desouza, Michael A. Tsoukas, Apussanee Boonyavarakul, Süleyman Ahbab, Haruo Ezaki, D. K. McGuire, Leanne K. Casaubon, Boris Mankovsky, Tina Tičinović Kurir, Patrick O’Donnell, C. Baker, E. Heyns, Naomi A. Wyatt, Carlos Eduardo Medina Pech, Terri Jerkins, D Levenson, Masayuki Tanaka, L. A. Ruyatkina, Miladin Djordjevic, Stephen C. Bain, Simona Cernea, Aytekin Oğuz, R. Prager, M. Montero, Anja Olsen, Habib Bilen, C. N. Mbogua, Galyna Myshanych, Eren Gürkan, Fei Bian, Maria Suciu, Marianna Maranghi, S. Genovese, Michael Shechter, Tem Lom Fam, Lúcia de Noronha, O. Y. Shabelnikova, Anupam Prakash, Derek M. Huffman, Winston Gandy, H. Iwata, Hiroyasu Onaka, Masni Mohamad, Petro Kuskalo -, Dario Rahelić, Nicole Pant, S Chilka, Yael Sofer, Diego Espinoza Peralta, Daniel Pella, Esteban Jódar, Katarina S. Lalic, L Nardone, Roberto Citarrella, Guillermo González-Gálvez, S. S. Emerson, Barbora Doležalová, Kevin M. Pantalone, Sasa Kikovic, Jindřich Olšovský, Irit Hochberg, Scott S. Emerson, Viera Doničová, Curtis Jantzi, Julie A. Porter, Masahiro Natsuaki, P. Grimmer, Olena Petrosyan, Victor Vishlitzky, Martina Oznerova, Jong Eun Lee, Kun Ho Yoon, Shivam Sharma, Hideo Yuki, Е. В. Фролова, Antonio Di Carlo, Deenan Pillay, David Fitzpatrick, Carlos H. Barrios, Milena Mitrović, Sean Peterson, Robert S. Busch, Minoru Tanabe, Hiroshi Ohashi, T.K. Ong, Ishratullah Siddiqui, José Francisco Kerr Saraiva, Manoj Chadha, Masashiro Sugawara, Daniel Koleny, T. D. Powell, B Field, Л. А. Суплотова, Bipin Sethi, Saraswati Ghosh, Sophie Borot, Edita Stokić, S. Murthy, Cuong Dang, M. Araujo Ordoñez, P. Johnston, Ping Rao, Alexander V. Murray, Andrés Ángelo, Ajit S Khaira, C. Axthelm, M. E. Yanovskaya, Suzana Marušić, Z Jankovec, Lawrence Zemel, Wayman E. Turner, Cynthia Brinson, Francis C. C. Chow, F. Giorgino, Mark Hewitt, Donald Eagerton, A. Soto González, B Paschen, Brian G. Everhart, M. Sergeeva-Kondrachenko, Emilie Ruiz, Ж. Д. Кобалава, D. H. Brautigam, Joseph Reed, M. Anderson, S Pedersen, Héctor Molina, Bipin V. Daxini, Rolf Schlößer, Thomas Ransom, Nizar Daboul, Ana López Suárez, М. А. Куницына, Wan Mohamed, M. Bustamante Labarta, Kim Prier, Nur Kebapçı, Bianca-Margareta Mihai, L. Mayet, José Angel Garza Ruíz, V. S. Reddy, Nicolas Belmar, Daksh Sanjay Gupta, Y. Hata, W S Lane, Kyong Wan Min, Unnikrishnan Gopalakrishnan, M. P. Baruah, Thomas Idorn, N K Thulaseedharan, Yoshio Nishida, Hoang Minh Tran, R. Elizondo, Mads D.M. Engelmann, SENTHILKUMAR KRISHNASAMY, N Adam, Т. А. Лысенко, Nor Shaffinaz Yusoff Azmi Merican, V. Simegi-Djekic, A. Staudenmeyer, V. Wenzl-Bauer, G. Girithara, N. N. Pletea, D. Strajer, O. Otroshchenko, S. Hanackova Prasekova, V. Hundza, V. Makan, J. Arambasick, B. L. Gonzalez-Orozco
article en
1 citations

Abstract

In people with T2D and ASCVD and/or CKD but with overall mostly preserved eGFR, orally administered semaglutide, compared with placebo, did not significantly reduce adverse kidney outcomes but did slow the decline in eGFR.

Diabetes CareVol. 49(2)
University of North Carolina at Chapel Hill (US), Parkland Health & Hospital System (US), Dalhousie University (CA), Universidad Autónoma de Guadalajara (MX), Oregon Health & Science University (US), Friedrich-Alexander-Universität Erlangen-Nürnberg (DE), Novo Nordisk (Denmark) (DK), University of Washington (US), Kidney Research UK (GB), Yale University (US), MRC Clinical Trials Unit at UCL (GB), Southwestern Medical Center (US), Hospital Universitario Fundación Alcorcón (ES), Cancer Research And Biostatistics (US), NIHR Imperial Biomedical Research Centre (GB), Universitätsklinikum Aachen (DE), University Children's Hospital Tübingen (DE), King Edward VIII Hospital (ZA), D. F. Chebotarev State Institute of Gerontology of the National Academy of Medical Sciences of Ukraine (UA), Deutsches Diabetes-Zentrum e.V. (DE), Changhua Christian Hospital (TW), German Center for Diabetes Research (DE), Kidney Centre (PK), Heinrich Heine University Düsseldorf (DE), University College London (GB), Imperial College London (GB), University of Nebraska Medical Center (US), University of Tübingen (DE), The University of Texas Southwestern Medical Center (US), RWTH Aachen University (DE), University of KwaZulu-Natal (ZA)
American Diabetes Association, Amgen, Bristol-Myers Squibb, Eli Lilly and Company, Pfizer, AstraZeneca, GlaxoSmithKline, Sanofi, Biogen, CSL Behring, McMaster University, Amarin Corporation, Insulet Corporation, Dexcom, Intercept Pharmaceuticals, Amsterdam University Medical Centers, Nevro, British Heart Foundation, European Commission, Deutsche Forschungsgemeinschaft, Novo Nordisk, Servier, Aspen, Esperion Therapeutics, Wörwag Pharma, National Institute of Diabetes and Digestive and Kidney Diseases, Daiichi Sankyo Europe
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