Evaluating the Statistical Robustness of Randomized Controlled Trials of Spinal Cord Stimulation for Pain through the Use of Fragility Index
This study suggests that the majority of RCTs investigating primary pain outcomes after SCS therapy are robust with relatively high fragility scores. Reporting the fragility of outcomes in trials can provide a more comprehensive assessment of trial robustness and can further aid clinicians in interpreting trial results and making informed treatment decisions.
Authors
- Jay V. Karri (ORCID: https://orcid.org/0000-0002-4300-1711)
- Ryan S. D’Souza (ORCID: https://orcid.org/0000-0002-4601-9837)
- Faraj W. Abdallah (ORCID: https://orcid.org/0000-0003-2435-6186)
- Richard Brull (ORCID: https://orcid.org/0000-0002-7708-8843)
- Tristan Weaver
- Raghav Shah (ORCID: https://orcid.org/0000-0002-7673-8031)
- Larry J. Prokop (ORCID: https://orcid.org/0000-0002-7197-7260)
- Nasir Hussain (ORCID: https://orcid.org/0000-0003-0353-1002)
- Jordan Bozer
Institutions
- University of Maryland, Baltimore (US)
- St. Michael's Hospital (CA)
- Mayo Clinic (US)
- University of Ottawa (CA)
- University of Toronto (CA)
- Tenaris (United States) (US)
- Ottawa Hospital (CA)
- The Ohio State University Wexner Medical Center (US)
- Novem (Netherlands) (NL)
- Mayo Clinic in Arizona (US)
- Decision Sciences (United States) (US)
- Mayo Clinic in Florida (US)
- Northeast Ohio Medical University (US)
Publication Details
- Journal
- Anesthesiology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1097/aln.0000000000005876
- Primary Topic
- Pain Management and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00