Asthma outcomes in adults with Preserved Ratio Impaired Spirometry (PRISm): a cohort study

<title>Extract</title> Preserved Ratio Impaired Spirometry (PRISm) is usually characterized by reduced FEV<sub>1</sub> accompanied by a FEV<sub>1</sub>/FVC ratio above the lower limit of normal (LLN) [1, 2]. Some studies, however, have labeled it as a “restrictive” pattern when “PRISm” is accompanied by a reduction in Forced Vital Capacity (FVC) [3, 4]. Possibly, PRISm with normal FVC would be a borderline pattern between normal spirometry and airway obstruction because, in this scenario, a low FEV<sub>1</sub> value results in FEV<sub>1</sub>/FVC ratio close to the LLN; but without crossing the threshold that defines obstruction.

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Publication Details

Journal
ERJ Open Research
Published
2025-12-11
DOI
https://doi.org/10.1183/23120541.00851-2025
Primary Topic
Chronic Obstructive Pulmonary Disease (COPD) Research
Type
article
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Asthma outcomes in adults with Preserved Ratio Impaired Spirometry (PRISm): a cohort study

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article

Asthma outcomes in adults with Preserved Ratio Impaired Spirometry (PRISm): a cohort study

Jessica Regina Bertolino, Alcides Rocha, Cintia Fernanda Bertagni Mingotti, Ronei Luciano Mamoni, Eduardo Vieira Ponte, Daniel Antunes, Monique Olivia Burch, Maria João Silva
article en

Abstract

<title>Extract</title> Preserved Ratio Impaired Spirometry (PRISm) is usually characterized by reduced FEV<sub>1</sub> accompanied by a FEV<sub>1</sub>/FVC ratio above the lower limit of normal (LLN) [1, 2]. Some studies, however, have labeled it as a “restrictive” pattern when “PRISm” is accompanied by a reduction in Forced Vital Capacity (FVC) [3, 4]. Possibly, PRISm with normal FVC would be a borderline pattern between normal spirometry and airway obstruction because, in this scenario, a low FEV<sub>1</sub> value results in FEV<sub>1</sub>/FVC ratio close to the LLN; but without crossing the threshold that defines obstruction.

ERJ Open Research
Faculdade de Medicina de Jundiaí (BR)
Openalex Percentile: Top 42%
Chronic Obstructive Pulmonary Disease (COPD) Research
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